http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102605033-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10b468b0922705a884eb13e179dec4de |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-06 |
| filingDate | 2012-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7efc89f3f66680b870454a6816f8d05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_579b22ffe216b9af183001ca574beb20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e562099b035d7208e2c1c94f60eb1f1f |
| publicationDate | 2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102605033-B |
| titleOfInvention | Method for preparing cefazolin intermediate TDA |
| abstract | The invention provides a method for preparing intermediate cefazolin TDA (7-amino-3-[(5-methyl-1,3,4-thiadiazol-2yl)thiomethyl]-3-cephalosporanicacid). The method comprises the following steps of: oxidizing cephalosporin C to be GL-7-ACA (glutaryl-7-aminocephalosporanic acid) by using D-amino acid oxidase; reacting with 2-methyl-5-sulfydryl-1,3,4-thiadiazole; removing glutaryl by using GL-7-ACA acylase to finally obtain TDA. The method provided by the invention improves a TDA synthetic route. By using reaction and synthesis based on the biological enzyme method, the method is green and environment-friendly and has no pollution. The problems in chemical production, such as large organic solvent using amount and long synthetic route, can be solved. Furthermore, thiadiazole can be recycled, so that the product quality is improved, the using amount of side chain is reduced, and the method is applicable to the industrial production. |
| priorityDate | 2012-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.