http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102604076-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4b1eac93fa8426bfd541c9e14e11860 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2012-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_672e0b4a6c9ae755b3f4b9d8aaa2dc46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f04dabe2b2cf0ac6f0bd9f2a3a715dfe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a08d7d075bfc66af8ad64988c98a078f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48fa3a227761a322c009558fe96ff08a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_323104024aeca5847b9f0b817d6ff158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1672d7224eb6705d62574f434d8b6a67 |
| publicationDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102604076-B |
| titleOfInvention | Multifunctional polyethylene glycol-dual vitamin E succinate derivative and application thereof in drug delivery |
| abstract | The invention relates to a multifunctional polyethylene glycol-dual vitamin E succinate derivative and application thereof in drug delivery. An amphiphilic block copolymer utilizes polyethylene glycol as a hydrophyllic end to be combined with bimolecular hydrophobic vitamin E succinate under bridging of lysine, so that the AB2 type two-arm amphiphilic block copolymer is obtained. The polymer has potential antineoplastic activity and P-gp inhibitory action, and is capable of synergetically and effectively overcoming multidrug resistance to increase chemotherapeutic effect. Besides, the block copolymer can be self-assembled to form a micelle in aqueous medium, and can serve as a reservoir of poorly water-soluble drug, protein and gene-based drug, and the micelle is safe and high in stability and encapsulation, can be used for intravenous injection and oral ingestion, and has bright market application prospects. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112006986-A |
| priorityDate | 2012-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.