http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102603912-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 |
| filingDate | 2012-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa1916dc3582b224092112fd34f3a67d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_275c21a084135939c9fe5676287c0231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5136e5c967a368f4010d7e042fc3195d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1e1338bebde81cb8085f4f1c1153fe1 |
| publicationDate | 2014-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102603912-B |
| titleOfInvention | Natural pullulan nano drug carrier and method for preparing same |
| abstract | The invention relates to a natural pullulan nano drug carrier, which is made of carboxymethylation pullulan and hydrazine under condensation reaction, wherein the condensation reaction degree of carboxyl of the carboxymethylation pullulan with amino of the hydrazine is 60-90%. The carriers with drug are automatically combined in water to form nano particles with particle size ranging from 60nm to 200nm. The preparation method includes the steps: firstly, preparing carboxymethylation pullulan; and secondly, using deionized water to make the carboxymethylation pullulan into solution with concentration being 0.01-0.10g/ml, using deionized water to make hydrazine into solution with concentration being 0.1-0.5g/ml, mixing while adding carboxymethylation pullulan aqueous solution into the hydrazine solution at room temperature and normal pressure, well mixing, adding 1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride aqueous solution with concentration being 0.5-1g/ml, mixing for reaction for two to six hours, using deionized water for dialyzing to remove micromolecular impurities after reaction is completed, and freeze drying to obtain the natural pullulan nano drug carrier. |
| priorityDate | 2012-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.