http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102603646-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30838059612d9ee73f52752c465f0244 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30ec8f5f5c79e6355a1277a9d37b9635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3d7162b95afa939213979b8b4861284 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05df9a7c8c2f00f6c8acdf2fe68af981 |
| publicationDate | 2012-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102603646-A |
| titleOfInvention | Synthesis of 4-[4-(methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)-1H-imidazole |
| abstract | The invention discloses a new method for synthesizing 4-[4-(methylsulfonyl)phenyl]-5-phenyl-2-(trifluoromethyl)-1H-imidazole, which belongs to the technical field of organic chemical synthesis. The steps include: reacting thioanisole and acetyl chloride to generate 4-methylthioacetophenone; then reacting with methyl benzoate to generate 1-(4-methylthiophenyl)-3-phenyl-1,3-dione ; Reaction with tert-butyl nitrite to generate 1-(4-methylthiobenzene)-2-phenyl-1,2 dione; Reaction with trifluoroacetaldehyde methyl hemiacetal to generate 4-[4- (Methylthio)phenyl]-5-phenyl-2-(trifluoromethyl)-1H-imidazole; finally oxidized to generate the 4-[4-(methylsulfonyl)phenyl]-5-benzene -2-(trifluoromethyl)-1H-imidazole. The synthesis method of the invention avoids the use of cyanide and the destruction of carbon-carbon double bonds by KMnO 4 , and has industrial application value. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114031520-A |
| priorityDate | 2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID466673452 |
Total number of triples: 15.