http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102603613-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 |
| filingDate | 2012-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102603613-B |
| titleOfInvention | 4-(methoxycarbonyl)-4-(N- phenylpropionamido)- piperidine-1-substituted compound, preparation method and pharmaceutical application |
| abstract | The invention relates to a 4-(methoxycarbonyl)-4-(N-phenylpropionamido)-piperidine-1-substituted compound, a preparation method and pharmaceutical application. The compound is of a structure of free base in a formula (I) or corresponding hydrochloride (I'), wherein in the formula, n is an integral number in the range of 0 to 3 and R is a sulfonyl group or a substituent group with a propofol parent nucleus structure. The compound has excellent water-solubility and stability and can simultaneously have effects of alleviating pain and calming, is suitable for carrying out pain alleviation and calming on a postoperative monitored patient and is particularly beneficial for implementing the operation of the patient on a self-control drug delivery system and the operation of an anesthetist can be reduced. The basic method for preparing the compound comprises the following step that according to the property of the substituent group R, the 4-(methoxycarbonyl)-4-(N-phenylpropionamido)-piperidine-1-substituted compound can be formed by carrying out condensation on a compound with a remifentanil parent nucleus structure and a compound with a corresponding substituent group parent nucleus structure. The invention provides the 4-(methoxycarbonyl)-4-(N-phenylpropionamido)-piperidine-1-substituted compound. |
| priorityDate | 2012-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.