http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102603604-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5a2ff1533dee5993c4504987cf43302 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-273 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-273 |
| filingDate | 2011-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b95487f93a6ca70d1766929e74b1a0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7fbfe76e49db08b563c07a0becec628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25888817bd892f8ad79eb3f28b769f2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd85dcbbb6fef84751bc2e2349224a6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc9f5bda74e56dc1f991c9e3cccd8b32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23376dbf0b2824d124810d7e56f7cb44 |
| publicationDate | 2014-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102603604-B |
| titleOfInvention | Preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide |
| abstract | A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide comprises the steps of conducting a reaction of a glycine ethyl ester hydrochloride with (S)-4-halogen-3-hydroxy-ethyl butyrate in an alcohol solvent under an alkaline condition, wherein the glycine ethyl ester hydrochloride and the (S)-4-halogen-3-hydroxy-ethyl butyrate are taken as raw materials, washing with inorganic alcohol, concentrating, then extracting, separating and introducing ammonia water to prepare a crude product, and purifying the crude product; and dissociating the glycine ethyl ester hydrochloride into glycine ethyl ester by diethyl ether and ammonia gas firstly. According to the preparation method, the main raw materials are (S)-4-halogen-3-hydroxy-ethyl butyrate and the glycine ethyl ester hydrochloride, which are low in cost, easy to obtain, environment-friendly and free of pollution; the glycine ethyl ester hydrochloride is subjected to dissociation firstly, so that the using amount of the materials in the reaction is reduced effectively, the cost is lowered, and in addition, the glycine ethyl ester hydrochloride plays an active role in the reaction yield. According to the prepared (S)-oxiracetam, the cost is low, the yield is high and reaches up to 36%, the reaction condition is moderate, the industrialized scale production is facilitated, and the HPLC (high-performance liquid chromatography) purity of the prepared (S)-oxiracetam reaches up to more than 98.5%. |
| priorityDate | 2011-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.