http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102586195-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5127fe8b5461c986356d7da71502405a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 |
| filingDate | 2011-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15b4728fa50ba259b54a26f1a1cdbe04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c26341f6165c3c1cbec9393435e16824 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebe9fd319e284ac5cdbcc82e349f5b6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ce8394b7ace115bba205439c3920633 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fdf3107c4d49c870673c62df583c2ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12434d14c770a8a4e392f8dcff51612c |
| publicationDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102586195-B |
| titleOfInvention | Method for preparing avian influenza virus and inactivated vaccine thereof with Vero passage cells |
| abstract | The invention discloses a method for preparing an avian influenza virus and an inactivated vaccine thereof with Vero passage cells. According to the method disclosed by the invention, the Vero passage cells are adopted to replace chicken embryo to culture influenza virus, so that the problems of chicken embryo remnant and exogenous virus inflection are solved and the immunogenicity of the cultured virus is more stable. On the other hand, for avoiding the phenomenon that the cracking of HA is influenced because protease is acted by an inhibitor in a maintaining liquid to inactivate, pancreatinis coated with chitosan and then is added in a cell maintaining liquid, so that the pancreatin is slowly released in the maintaining liquid and the defect that the cracking of hemagglutinin is influenced because the pancreatin is inactivated in the reproduction process of viruses is overcome. In addition, the probability that the cells are polluted since the pancreatin is added for multiple timesis avoided. The virus cultured by the method disclosed by the invention is high in titer and favorable in stability and is suitable for large-scale vaccine production. |
| priorityDate | 2011-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.