| abstract |
The invention relates to a compound represented by the following general formula, a pharmaceutically-acceptable salt or a solvate of the compound, a biotransformation method of the compound and application of the compound in preparing medicaments for preventing and treating hepatitis C and other related viral diseases, wherein R1-R7 are same or different and are independently selected from hydrogen, C1-C8 alkoxy group, C1-C8 alkanoylxy group, C1-C8 alkyl sulfooxy, halogen, amino group, nitro group, cyan group, hydroxyl group or carbonyl group; a and b are both a double bond, or c is a double bond and a and b are both a single bond; and R8 can be same or different, and is independently selected from -COOH, -CH3, -CH2OH, -COOR9, -CONH2, -CONHR9 or -CON(R9)2, wherein R9 is C1-C8 alkyl, substituted or unsubstituted benzyl, or substituted or unsubstituted benzyl (C1-C8)alkyl, or R8 can form a five-membered ring with R6 through an ester bond. |