http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102584709-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-68 |
| filingDate | 2011-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2cdf9b96b98ce22fdf769229892ff42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04446ef8864f9656f56e23a3fd35dcb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e07549d9f8cfcca63c6a9d1239c3092a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0dbb5b1d9ef7893b810036df2c27e20 |
| publicationDate | 2012-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102584709-A |
| titleOfInvention | A kind of preparation technology of improved eprosartan intermediate aryl imidazole aldehyde |
| abstract | The invention discloses a preparation process of an eprosartan intermediate aryl imidazole aldehyde, that is, methyl esterification of p-chloromethylbenzoic acid is carried out to obtain methyl p-chloromethylbenzoate; Methyl formate and imidazole aldehyde use DMF as the reaction solvent and potassium carbonate as the base to stir and react at 20-40°C; after the reaction is completed, remove potassium carbonate by filtration; add water to the filtrate to crystallize while stirring; recover the aryl group of eprosartan intermediate imidazole aldehyde. The process has the advantages of high yield, high product purity, low N-isomer impurities, extremely low dimer impurities, etc., can be used in the next step without refining, and is suitable for large-scale industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111978257-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104788382-A |
| priorityDate | 2011-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.