http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102584707-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7cc8f1d18d8beb7a690a27ce5e5952e8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-48 |
| filingDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2ed9d0d36b3280f7b96df6fdec233b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7723aa77fe4c5a37479cad792ca4aa0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b09b0b22d686de111a9ddd986915e58c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ee309140b49b4a0a87618c24570daad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_681fbef28d1e17200a0ac3098d327968 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac6e676298af6076ba1570610b5fa844 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57f69316dcc41a8d721ed1de1abe244e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7540d313df61da89ebf5db56f906fa44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e99cc6b7ea42819f192ed32eed79cf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d217f1b0d9fed0b66a9351294d98d08 |
| publicationDate | 2014-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102584707-B |
| titleOfInvention | Production method of analgin bulk drug |
| abstract | The invention discloses a production method of analgin bulk drug and belongs to the pharmceutic field. The production method particularly comprises the following steps: step 1: antipyrine is taken as a raw material, and 4-amino-antipyrine oil is obtained through nitrosification, reduction, hydrolyzation and neutralization reaction; step 2, formylation is performed on 4-amino-antipyrine so as to obtain 4-formylaminoantipyrine; step 3: 4-dimethylaminoantipyrine is prepared through methylation, hydrolyzation, and neutralization reaction of 4-formylaminoantipyrine; step 4: 4-formylaminoantipyrine is prepared to be analgin solution through condensation reaction; step 5: the analgin solution obtained from the step 4 is refined and crystallized, and finally, analgin is prepared. In the invention, by improving the conventional manufacturing technique, the purity of analgin product is improved, contains of other unknown impurities are reduced, the colourimetric number is lower and the crystallization color is whiter. |
| priorityDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.