| abstract |
The invention relates to a method for preparing 4-substituted amidocyclohexanone by oxidation of 4-substituted amidocyclohexanol, and the 4-substituted amidocyclohexanone prepared by the method can be used to prepare pramipexole. The method is as follows: in an organic solvent, add 4-substituted amidocyclohexanol shown in formula I, catalyst 2,2,6,6-tetramethylpiperidine-nitrogen-oxide, NaBr, and then add dropwise The sodium hypochlorite aqueous solution is reacted until the oxidation reaction is complete, and the reaction solution is separated and purified to obtain the 4-substituted amidocyclohexanone shown in formula II; the beneficial effects of the present invention are mainly reflected in: a new method for the production of pramicone has been found. The chemical synthesis method of the key intermediates makes the route more reasonable, the reaction conditions are milder, the yield is higher, and the environment is more friendly. It is a method suitable for large-scale industrial production. |