http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102580115-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4711b7defc1422cdb7f86d2c95657bf |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2011-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d8566c1c4f4cac12d0ded6e68bfa53f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fa5037d645b46252e7f8689d9c9415b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf09618dca45d6c260c51246b0e7685b |
| publicationDate | 2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102580115-B |
| titleOfInvention | Tuberculosis mucosa gene vaccine assembled by using chitosan oligosaccharide delivery system and preparation and application of tuberculosis mucosa gene vaccine |
| abstract | The invention discloses a tuberculosis mucosa gene vaccine assembled by using a chitosan oligosaccharide delivery system. The vaccine is formed by copolymerizing, crosslinking and compounding a chitosan oligosaccharide and a tuberculosis antigen encoding plasmid; a full-length gene of a heat shock protein HSP65 derived from a mycobacterium tuberculosis H37Rv strain is inserted into the tuberculosis antigen encoding plasmid; and four T cell epitope genes, namely, ESAT-6189-228, Ag85A369-405, CFP10162-207 and Ag85B420-459 derived from the mycobacterium tuberculosis H37Rv strain are inserted into the HSP65 full-length gene. The invention further discloses a preparation method and an application of the tuberculosis mucosa gene vaccine. The tuberculosis mucosa gene vaccine disclosed by the invention can be used for inducing tuberculosis specific serum antibodies and systemic Th1 immune response, can be used for inducing lung mucosa locally-enhanced tuberculosis specific secretion type SIgA and IFNgama+Th1 response, and has a remarkably superior effect to that of a naked pECANS gene vaccine. |
| priorityDate | 2011-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.