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grantDate 2013-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb94c1cfc3c8ae52435e7566f216d84b
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publicationDate 2013-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102579407-B
titleOfInvention Preparation method for indapamide microsphere sustained release capsules
abstract Provided is a preparation method for indapamide microsphere sustained release capsules. The indapamide microsphere sustained release capsules, especially contents, are formed by microsphere of gastrointestinal tract release medicine manufactured by indapamide and high polymer materials with high potential of hydrogen (pH) dependency. The high polymer materials comprise polyacrylate E-100, hydroxypropyl methylcellulose phthalic ester HP-55 and hydroxypropyl methylcellulose succinate HAS which are respectively manufactured into stomach dissolving microsphere, intestines dissolving microshpere and colon dissolving microsphere with the indapamide. All microspheres are combined into particle dispersing capsules according to weight parts. After taken, medicine is released in the stomach and intestines according to pH gradient, blood concentration is stable, sustained release is achieved, medicine in the microsphere is highly dispersed and dissolved out to be completely absorbed, and biological utilization of oral medicine is improved. The medicine microsphere is simple in the preparation method and equipment and suitable for industrialization.
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