http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102579373-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2012-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34cfd89b9512fe07aacd2a49fb50e23c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_234057aa14d31fbcee3f517326d2f20e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a52a237c8cd97d5b761cd511bc85e873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1811ca1580a0b0381707926733378e66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76fed3f5254890608388b2e66418275d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81fda5020394e8add5bc4ad6d15a3330 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efb5f2921d1c9b09ddb2349523c1d70c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36ba5b2c6d4217e59c0395101978ab14 |
| publicationDate | 2013-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102579373-B |
| titleOfInvention | Amoitone B nano crystallization preparation and preparation method thereof |
| abstract | The invention relates to an Amoitone B nano crystallization preparation and a preparation method thereof. The adriamycinone derivative nano crystallization preparation comprises raw material drug Amoitone B, stabilizers and a cryoprotectant. The stabilizers include a surfactant and a high polymer suspending agent. The preparation method is a high pressure micro jet method. The Amoitone B nano crystallization preparation provided by the invention can be used for obviously improving the solubility and the dissolution rate of the Amoitone B and implementing uniform controllability of the particle size in the range of 200 to 1,000 nm by controlling the prescription ratio and micro jet homogeneous parameters and has the advantages of good biocompatibility, easiness in degrading, high stability, high efficiency and low toxicity, passive targeted transmission and the like. A carrier and an organic solvent are not contained in the prescription of the Amoitone B nano crystallization preparation, so that the Amoitone B nano crystallization preparation has high administration safety when being used for intravenous injection and can be developed into an oral preparation to improve the bioavailability. The high pressure micro jet method is simple in preparation process, good in reproducibility and stable and is convenient to industrial mass production. |
| priorityDate | 2012-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.