| abstract |
The object of the present invention is to provide a low-molecular compound and its pharmaceutical application. The low-molecular compound has p38MAPK inhibitory activity and accompanying TNFα production inhibitory activity, and realizes good pharmacokinetic profile and reduced liver toxicity as a drug. The present invention provides 2,3-dihydro-1H-inden-2-ylurea derivatives represented by the following formula; pharmaceutically acceptable salts thereof; and allergic dermatitis containing the derivatives or pharmaceutically acceptable salts thereof as active ingredients , a therapeutic or preventive agent for inflammatory bowel disease and pain. |