http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102558569-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_abca4085957106c1eabf66934010b4b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c345a2abb6cce10c6e96650b050c792 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2012-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29358aae3c3de79a445e3824dc8dcba6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67634e4b29ecbb27d7c60b82e4a7dc11 |
| publicationDate | 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102558569-B |
| titleOfInvention | Lipopolysaccharide amine cationic polymer and preparation method and application thereof |
| abstract | The invention discloses a lipopolysaccharide amine cationic polymer, which is synthesized with hydrophilic polyaldehyde-based sodium alginate is adopted as a main chain, hydrophobic cholesterol capped polyethylene imine of low molecular weight as a side chain. The physical and chemical structure, buffering capacity, transfection efficiency and cytotoxicity of the lipopolysaccharide amine cationic polymer are characterized. According to exploration of the feasibility of use as a gene carrier and the effects on improvement of the gene transfection efficiency and reduction of the cytotoxicity, the polymer has advantages of good biocompatibility, controllable degradation performance, low cytotoxicity, high safety and practicality and low cost, and the transfection efficiency of GFP (green fluorescent protein) in MSCs (mesenchymal stem cells) is higher than 95 percent regardless of the presence or absence of serum. Moreover, the polymer can be used as a gene carrier and other drug carriers such as anticancer drugs, RNA (ribose nucleic acid) carriers and the like. The invention also discloses a preparation method and application of the polymer. |
| priorityDate | 2012-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.