| abstract |
The invention relates to a preparation method of tebipenem pivoxil and analogue thereof. In the method, carbapenem compound salt with a formula II is used as a raw material to obtain carbapenem compound ester with a formula I under the action of alkali, wherein the carbapenem compound salt with the formula II is prepared by direct reaction of a carbapenem compound with a formula III and ester with a formula IV. According to the invention, high-yield and high-purity salt of tebipenem pivoxil and analogue thereof can be prepared, so that high-yield and high-purity tebipenem pivoxil or analogue thereof can be obtained without column chromatography. Thus, the method provided by the invention is more suitable for industrial production in a large scale. |