http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102552159-B

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grantDate 2013-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102552159-B
titleOfInvention Rabeprazole sodium enteric-coated micro-pellet and preparation method thereof
abstract The invention belongs to the field of medicament preparations, and relates to a rabeprazole sodium enteric-coated preparation and a preparation method thereof. A rabeprazole sodium enteric-coated micro-pellet disclosed by the invention comprises a blank pellet core, a medicament carrying layer, an isolating layer and an enteric-coated layer from inside to outside, wherein the weight increment of the medicament carrying layer is 10-20 percent; the weight increment of the isolating layer is 5-10 percent; the weight increment of the enteric-coated layer is 30-50 percent; the medicament carrying layer consists of rabeprazole sodium, hydroxypropyl methyl cellulose and talc powder; the isolating layer consists of copovidone, a plasticizing agent, talc powder, titanium dioxide and a stabilizing agent; the stabilizing agent is one or more of magnesium oxide, calcium oxide, sodium carbonate, sodium bicarbonate, potassium carbonate and potassium bicarbonate; and the enteric-coated layer consists of an enteric-coated material, a plasticizing agent, talc powder and titanium dioxide. The rabeprazole sodium enteric-coated micro-pellet disclosed by the invention has the effects of high solubility and high stability.
priorityDate 2010-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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