| abstract |
The present invention discloses a compound of formula (i) or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein a is formula (ii); q is a substituted 5-membered monocyclic heteroaryl; w is ch 2 , o or nh; And r 1 , r 2 , r 3 , r 4 , r 5 , r 6 , m, n, t and x are as defined herein. The invention also discloses a method of using the above compound as a selective agonist of G protein-coupled receptor s1p 1 and a pharmaceutical composition comprising the above compound. These compounds are useful in treating, preventing or slowing the progression of diseases or disorders, such as autoimmune and vascular diseases, in a variety of therapeutic areas. |