http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102548976-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5375 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D419-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2010-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102548976-B |
| titleOfInvention | As (sulphur) morpholine derivative of S1P conditioning agent |
| abstract | The present invention relates to (sulphur) morpholine derivative of following formula (I), wherein R1 is selected from: cyano group, (2-4C) alkynyl, (1-4C) alkyl, (3-6C) cycloalkyl, (4-6C) cycloalkenyl group, (6-8C) bicyclic alkyl, (8-10C) bicyclic groups, eachly optionally replaced by (1-4C) alkyl; Phenyl, xenyl, naphthyl, eachly optionally replaced independently selected from following substituting group by one or more: halogen, (1-4C) alkyl optionally replaced by one or more fluorine atom, (2-4C) alkynyl, optionally by (1-4C) alkoxyl group, amino, two (1-4C) alkylamino ,-SO that one or more fluorine atom replacesn 2 -(1-4C) alkyl ,-CO-(1-4C) alkyl ,-CO-O-(1-4C) alkyl ,-NH-CO-(1-4C) alkyl and (3-6C) cycloalkyl; By the phenyl that phenoxy group, benzyl, benzyloxy, styroyl or monocyclic heterocycles replace, each substituting group is optionally replaced by (1-4C) alkyl; Optionally by monocyclic heterocycles that following substituting group replaces: halogen, (1-4C) alkyl or optionally by the phenyl that (1-4C) alkyl replaces, with optionally by bicyclic heterocycles that (1-4C) alkyl replaces; A is selected from :-CO-O-,-O-CO-,-NH-CO-,-CO-NH ,-C=C-,-CCHn 3 -O-and linking group-Y-(CHn 2 )n n -X-, wherein Y and R1 is connected, and is selected from: key ,-O-,-S-,-SO-,-SOn 2 -,-CHn 2 -O-,-CO-,-O-CO-,-CO-O-,-CO-NH-,-NH-CO-,-C=C-and-C ≡ C-; N is the integer of 1-10; And X is connected with phenylene/pyridyl, and be selected from: key ,-O-,-S-,-SO-,-SOn 2 -,-NH ,-CO-,-C=C-and-C ≡ C-; Ring structure B is optionally containing 1 nitrogen-atoms; R2 is H, is optionally replaced (1-4C) alkyl, optionally by (1-4C) alkoxy or halogen that one or more fluorine atom replaces by one or more fluorine atom; And R3 is (1-4C) alkylidene group-R5, wherein said alkylidene group can by (CHn 2 )n 2 replace and form cyclopropyl moieties, or replaced by 1 or 2 halogen atoms, or R3 is (3-6C) cycloalkylidene-R5 or-CO-CHn 2 -R5, wherein R5 is-OH ,-POn 3 hn 2 ,-OPOn 3 hn 2 ,-COOH ,-COO (1-4C) alkyl or tetrazolium-5-base; R4 is H or (1-4C) alkyl; R6 is one or more independently selected from following substituting group: H, (1-4C) alkyl or oxo; W is-O-,-S-,-SO-or-SOn 2 -; Or its pharmacy acceptable salt, solvate or hydrate; Condition is, the derivative of formula (I) is not 2-(4-ethylphenyl)-4-morpholine ethanol or 4-[4-(2-hydroxyethyl)-2-morpholinyl] benzyl cyanide, or its pharmacy acceptable salt, solvate or hydrate, compound of the present invention has the avidity to S1P acceptor, may be used for treatment, alleviates or prevent the receptor-mediated disease of S1P and illness. |
| priorityDate | 2009-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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