| abstract |
The present invention relates to the material of new formula (I), wherein: R1 is aryl or the heteroaryl of optional replacement; R is H, or forms 5-or 6-ring with R1, described 5-or 6-ring and aryl heteroaryl condense and one or more optionally containing in O, S, N, NH and Nalk, and it be optional replacement; R2 and R3 is independently for H, Hal or optionally by alkyl that one or more Hal replaces; R4 is hydrogen; And R5 is hydrogen or optionally by alkyl that one or more halogen atom replaces.Be intended to be used as medicine, particularly AKT (PKB) phosphorylation inhibitor with the described material of any isomeric form and salt thereof. |