http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102533921-B

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-02
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filingDate 2011-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4254d8215306573ac47bbcfba0bb0bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd34f1e112dd958831cdff1a3dcf7fbf
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publicationDate 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102533921-B
titleOfInvention Method and bacterial strains for preparing (S)-epichlorohydrin through microbial transformation
abstract The invention provides a method for preparing (S)-epichlorohydrin through microbial transformation, which includes the steps: using racemic epoxy chloropropane as a substrate, fermenting aspergillus niger with China center for type culture collection (CCTCC) NO: M2010275 to obtain somatic cells containing enzyme bacteria serving as a biological catalyst, performing selective catalytic reactions in organic solvent, and separating and purifying reaction liquid to obtain the (S)-epichlorohydrin after the reactions are finished, wherein the organic solvent is one of cyclohexane, normal hexane or heptane. The method and bacterial strains for preparing the (S)-epichlorohydrin through the microbial transformation has the advantages that (1) the method is simple in steps, low in pollution and friendly in environment; (2) immobilized cell granules serving as the biological catalyst has high enantiomer selectivity, and high optical purity of the (S)-epichlorohydrin is guaranteed; and (3) cycling resolution of by-products and recycling of the biological catalyst greatly reduce raw material cost and production cost.
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