http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102532411-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f90c1df3857ee72900e0015c75caecd9 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F2-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-32 |
| filingDate | 2011-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e6a572a2f0edc1f0c71db3296b08e44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec28a9462cd9f4cc46eddb41339839ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b35fdd430443a1a3354953b70143e29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e256f31eed82d8c39a424bb85247e19 |
| publicationDate | 2013-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102532411-B |
| titleOfInvention | Functional oligomer used for non-viral gene vector material and application thereof |
| abstract | The invention provides a functional oligomer used for a non-viral gene vector material. The functional oligomer is prepared by free radical polymerization of MA-His-OMe and MAEL through taking water-soluble thio ester as a molecular weight regulating agent. In the preparation method, MA-His-OMe and MAEL are used as monomers, AIBN (2,2-azobisisbutyronitrile) or ACVA (4,4'-azobix(4-cyano valeric acid)) is used as an initiator, and CPADB (4-cyanopentanoic acid dithiobenzoate) is used as a chain transfer agent. According to the invention, the functional oligomer is mixed with a polycation material to prepare a DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) composite which is used as the non-viral gene vector material and a cell transfection experiment is carried out. The functional oligomer has the advantages that the functional oligomer has a good protection effect on plasma DNA and can be used for improving the binding action of a complex particle and a cell membrane surface and improving the escape efficiency of the plasma DNA from lysosme/endosome in a cell, thus the transfection efficiency of the complex particle on cells such as HeLa is greatly improved, and the toxicity of the functional oligomer is greatly reduced, therefore the functional oligomer is expected to reach a clinical application level. |
| priorityDate | 2011-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.