| abstract |
The invention provides an asymmetric synthesis method of (S)-N,N-dimethyl-3-hydroxyl-3-(2-thienyl)propylamine, the main step of which is (R)-(+)-α , α-diaryl prolinol or (R)-(+)-α, α-diaryl prolinol silicon ether is used as a catalyst, and metal hydride complexes such as sodium borohydride and potassium borohydride are used for reduction Reagent, reduced to (S)-N, N-dimethyl-3-hydroxyl-3-(2-thienyl) propylamine. The method is simple and feasible, has high yield and optical purity, and is suitable for large-scale production. |