http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102532070-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102532070-B |
| titleOfInvention | One class is as the natural product and uses thereof of retinoid receptor (RARs) agonist |
| abstract | The invention discloses the natural product and uses thereof of a class as retinoid receptor (RARs) agonist, the present invention finds that marine natural product Luffariellolide and Manoalide is the specific agonist of retinoid receptor RARs, and sets forth this species specific selectivity based on molecular structure level.It should be noted that both can suppress the growth of kinds of tumor cells by retinoid receptor RARs, comprise colon cancer cell vitamin A acid being had to resistance.The present invention summarizes the medical effect of Luffariellolide and Manoalide by great many of experiments, discloses the signal path mechanism of this many-sided drug effect medicine not clear so far from the interaction of it and nuclear receptor RARs.From molecular structure level, the covalent attachment pattern that Late Cambrian RAR and Luffariellolide part are formed.Present invention shows that such marine natural product and derivative thereof can provide a kind of layout strategy effectively to alleviate the medicine of resistance with research and development for Tumor suppression growth. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106619612-A |
| priorityDate | 2011-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.