http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102531955-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ad10a150dafec3cb3528ab9e1de9f92 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C245-08 |
| filingDate | 2011-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a752bd8a630b13a0e6566bfca5e76c1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abd29c7b66c59c8f61974eed5cc34428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df410e7adc648c805b310df09dce838 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb8bdfbc58294f863f55ad63d97ecbc6 |
| publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102531955-B |
| titleOfInvention | Preparation method of olsalazine disodium and postprocessing method of methyl sulfonation reaction |
| abstract | The invention relates to a preparation method of olsalazine disodium and a postprocessing method of methyl sulfonation reaction. The preparation method uses salicylic acid as a raw material, and the olsalazine disodium is prepared by nitratlon reaction, esterification reaction, the methyl sulfonation reaction, reduction reaction, diazotization coupling reaction and hydrolysis reaction, ice water mixture is added in reaction liquid after the methyl sulfonation reaction in a methyl stlfonation reaction process is completed to process and collect 2-methyl sulfonyl oxygen-5-nitryl methyl benzoate, and the mass ratio of ice to water in the ice water mixture is 0.1:1-10:1. The postprocessing method of the methyl sulfonation reaction is that the ice water mixture is added in the reaction liquid after the methyl sulfonation reaction is completed to process and collect products, and the mass ratio of ice to water in the ice water mixture is 0.1:1-10:1. The method is simple and non-toxic, prepared products are few in impurities, the productivity is higher than 85%, and effects are obvious. |
| priorityDate | 2011-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.