| abstract |
The invention discloses a natural product bostrycin derivative ii, its preparation method and application. The natural product bostrycin derivative ii has the structure of general formula (i), When r 8 =h, r 7 =nhr 9 or Where: r 9 = straight or branched alkyl, unsaturated alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, aralkyl, alkyl containing hydroxyl and alkyl containing hydroxyl and ether bond base; r 10 = h, straight or branched alkyl, unsaturated alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, y = c, o, n; when r 8 = r 7 = When sr 11 , wherein: r 11 = straight or branched alkyl of c1-c12, unsaturated alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, hydroxyalkyl of c2-c11; ch 2 (ch 2 ) n cooh, n=1-5. The natural product bostrycin derivatives involved in the present invention, preliminary pharmacological studies (in vitro anti-tumor cell test), results show that these compounds have good anti-tumor cell activity, and can be further developed into new anti-tumor drugs. |