http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102526712-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aaadcd534c1edeab62f85ec7991cb759 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 |
| filingDate | 2012-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b049c5c41a318911a882852a4146a65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d5f6007ec91da2fbebe4fe01b55e948 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffc5acab7bc597ac6cd8324092ed681e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09399f270a32d1f80a26dc5a6766928d |
| publicationDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102526712-B |
| titleOfInvention | Application of super oxygen dehydrogenises-trans-activator transcription (SOD-TAT) fusion protein to radiation injury prevention and cure medicine preparation |
| abstract | The invention relates to the field of fusion protein, in particular to an application of super oxygen dehydrogenises-trans-activator transcription (SOD-TAT) fusion protein to radiation injury prevention and cure medicine preparation. A preparation method of the SOD-TAT fusion protein has the steps that: the genetic recombination technology is adopted, TAT is fused to the C end of SOD according to gene sequences of human CuZn super oxygen dehydrogenises in a genbank, a new protein SOD-TAT is formed, expression plasmids fused with the SOD and the TAT are built, the efficient expression in pichia pastoris is obtained, and finally, high-purity SOD-TAT fusion protein is extracted from fermentation liquor of the pichia pastoris through ion exchange; and the SOD-TAT fusion protein is used for preparing radiation injury prevention and cure medicine. The SOD-TAT can eliminate free radicals outside cells and can also eliminate free radicals in the cells, in addition, the SOD-TAT can also overcome hemato encephalic barrier, and the depth and the range of the radiological protection effect are far higher than those of radiation protection agents clinically used in the prior art. |
| priorityDate | 2012-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.