| abstract |
The invention relates to an aspirin solid dispersion, as well as a preparation and use thereof. The aspirin solid dispersion provided by the invention is prepared by taking a methoxy-terminated polyethylene glycol-polylactic acid block copolymer and derivatives thereof, polylactic acid, a polylactic acid-glycollic acid copolymer or polycaprolactone as carrier materials and performing preparation through a solvent method or a hot melting method. According to the preparation method of the aspirin solid dispersion, provided by the invention, hydrolysis of aspirin can be avoided, and toxicity and side effects can be further reduced. The aspirin solid dispersion provided by the invention can be used for relieving fever, relieving pain, resisting rheumatic fever, resisting rheumatism or rheumatoid arthritis and resisting thrombus by subcutaneous or intramuscular injection. |