http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102516536-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3128c49d9d6cc01c2654df8950f4399b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-04 |
| filingDate | 2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f2f50935db8346819344d5099a2eef1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65beefa22d8d1a0e22726efd9864f2d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41720902de7822f99de1f4d877c4aa7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3229aef37e4ecbaec1aa81ddd53256e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afde6b287530e86b23b3ad0661660b9d |
| publicationDate | 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102516536-B |
| titleOfInvention | Polyethyleneimine (PEI) derivative taking amphipathic chitosan as cross linker and preparation method and application thereof |
| abstract | The invention relates to a polyethyleneimine (PEI) derivative taking an amphipathic chitosan as a cross linker. The molar ratio of the amphipathic chitosan to PEI in the derivative is 1:(1-20), the molecular weight range of the PEI in the raw materials for the preparation of the derivative is 600-70,000, and the molecular weight range of the chitosan in the raw materials for the preparation of the derivative is 1,000-50,000. The invention further provides a preparation method and application of the derivative. The PEI derivative has the advantages that: the PEI derivative is connected with low-molecular-weight PEI through a chemical cross-linking method by using the advantages of the chitosan, and the cytotoxicity arising from high-molecular-weight PEI is greatly lowered under the premise that a certain transfection efficiency is ensured; and particles can be prevented from aggregating in a blood circulation fluid environment due to the introduction of a hydrophilic surface by the chitosan, the stability is improved, the size of a complex formed by deoxyribonucleic acid (DNA) and the PEI derivative connected with the low-molecular-weight PEI can reach nanoscale, and thus, the PEI derivative is suitable for the in-vivo transmission of gene drug. |
| priorityDate | 2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.