http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102516350-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43b018a17f2be8e9f69a5b813d34bbb4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J69-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277 |
| filingDate | 2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3d6c1ec4a102a5c064aa01c4c088bca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd72e227d55e09810d0ae8c4cb421f71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2b14a8d1d5c19b190391fe4ad6a4b84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c44587467f5cfe6a0bd452669ca30437 |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102516350-B |
| titleOfInvention | Glycyrrhetinic acid modifier with antitumor activity and preparation method thereof |
| abstract | The invention relates to a glycyrrhetinic acid modifier with antitumor activity and a preparation method thereof, which relate to structural modification technology of glycyrrhetinic acid. The method comprises the following step that: after carrying out esterification on 30-bit carboxyl and alkyl chloride of the glycyrrhetinic acid, modifying an A loop to realize structural modification of the glycyrrhetinic acid so as to obtain a series of glycyrrhetinic acid derivatives (I 1-5, I I1-5, III 1-5, IV 1-5 and V1-5). Through a test, the glycyrrhetinic acid modifier has a certain inhibiting effect for human body cervical carcinoma HeLa cells, hepatocelular carcinoma HepG2 cells and gastric cancer BGC-823 cells. The structure of the glycyrrhetinic acid derivatives is shown in the description. |
| priorityDate | 2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.