http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102504013-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2effa7afdc95cf341ad587762458727d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2011-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81e91eb443c63b863665cc60da1b6d7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d122b23a29f2aff631fae31252d7db7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c10eda556c53fa4e17c4e293fa6340cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21f714da217fadd0c0fdf2673befd469 |
| publicationDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102504013-B |
| titleOfInvention | Target chemical drug PADM against cancer metastasis and preparation method and use thereof |
| abstract | The invention discloses a target chemical drug PADM against cancer metastasis and a preparation method and use of PADM. The chemical drug is high-purity PADM hydrochloride with the structure of Ac-Phe-Lys-PABC-ADM.HCl, prepared by purification. The method comprises the following steps of: (1) preparing Fmoc-Lys (MMT), (2) preparing Lys (MMT), (3) preparing Ac-Phe-Lys (MMT), (4) preparing Ac-Phe-Lys (MMT)-PABOH, (5) preparing Ac-Phe-Lys (MMT)-PAB-PNP, (6) preparing Ac-Phe-Lys (MMT)-PABC-ADM, and (7) preparing Ac-Phe-Lys-PABC-ADM.HCl, treating the residue with dichloromethane, and filtering to obtain the final product. The invention also discloses the use of the target chemical drug PADM for preparation of drugs for treating or preventing peritoneal carcinomatosis of gastric cancer. The method is simple and feasible and has stable process and higher yield, and the drug PADM has effective anticancer function. |
| priorityDate | 2011-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.