http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102503930-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 |
| filingDate | 2011-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_298eba204e3d7f4f05fd80fe43423cb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf8bbcfb55c039315ed779c661b2b0b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c40b2b72ab23a121c415b5d321d20cff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e423eeff4a6890dbb0e1edb88fa6ffd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cd232cf14bb078f34f43b3d08113a82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75eef9bb1f64242cfc838649d55bf83c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2eb777c98271991fe3916f2168c559e |
| publicationDate | 2014-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102503930-B |
| titleOfInvention | 3, 4, 5-tri-substituted aminothiopene chemical compound and preparation and application thereof |
| abstract | The invention provides a 3, 4, 5-tri-substituted aminothiopene chemical compound. Substituted benzene is used as a raw material to produce derivatives of the 3, 4, 5-tri-substituted aminothiopene chemical compound after being subjected to Friedel-Crafts acylation reaction, Knoevenagel condensation, cyclization, hydrolysis reaction and condensation. The chemical compound and salt thereof have evident effect on blocking interaction of p53-MDM2 (murine double minute 2) and evident inhibitory activity for proliferation in vitro of tumor cells according to demonstration of pharmacological experiments, and the IC 50 (half maximal inhibitory concentration) can reach the mu M level. The 3, 4, 5-tri-substituted aminothipene is reasonable in design, simple and convenient in preparation method and applicable to practical use and can be applied to preparation of antineoplastic medicines, raw materials for the 3, 4, 5-tri-substituted aminothipene are rich in sources, reaction conditions are mild and yield of each step of the preparation method is high. The structural formula of the 3, 4, 5-tri-substituted aminothipene is shown in the description. |
| priorityDate | 2011-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.