http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102499918-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_312804bd9173794765ee392ae754b1f4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-42 |
| filingDate | 2011-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b093202e8858a9ba32e37e09d400450c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6ce098faf24025560a8a19434e4c5e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23ace633e3267e3e8879e36147828bce |
| publicationDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102499918-B |
| titleOfInvention | Anti-radiation medicine and manufacturing method and application |
| abstract | The invention belongs to the medicine technical field, and in particular relates to an anti-radiation medicine in protection of human lung embryo fibroblast and radiation injury in experimental mice. The anti-radiation medicine has a structure of 4-methoxy benzylidene-2-substituted-5(4H)-oxazolone and derivatives thereof and can be expressed in structural formula (A). The invention has the advantages that compound (A) has a significant protection effect for DNA and genome injury to human lung embryo fibroblast (MRC-5) and experimental mice caused by ionizing radiation, such as X-rays, carbon ions, etc., and non-ionizing radiation, such as ultraviolet rays and microwaves; relative survival percentage of cells irradiated by said rays can be increased significantly; DNA injury can be reduced; instability of genome is reduced; MDA (malondialdehyde) yield of mice viscera can be reduced; and SOD (Superoxide Dismutase) activity of mice viscera can be enhanced. The invention has low toxicity, wide application range and good application prospect. |
| priorityDate | 2011-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 176.