http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102491974-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2883d7064ccc74371bf97aceef42963 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2011-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b364ad2f162a47552495a1429b8b807d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fe48d24d03076a8b6cd207bd79cbc50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5cf128347e6c703edcb761a038fb991 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdb706b4634c6d7d609822e70611a47b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d930bd373b0c58676d8ddde25b7c15f7 |
| publicationDate | 2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102491974-B |
| titleOfInvention | Method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride |
| abstract | The invention relates to the field of chemical synthesis, in particular to a method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride, which is an important intermediate of Riociguat that is an anti-thromboembolic-disease medicine. The method is characterized in that: 3-iodo-1H-pyrazolo[3,4-b]pyridine is used as a raw material; the raw material is reacted with fluorobenzyl bromide to form a compound (10); the compound (10) is reacted with zinc cyanide to form a compound (6); the compound (6) is reacted with sodium methoxide, ammonium chloride, acetic acid and methanol to form a compound (8); and the compound (8) is reacted with chlorine hydride gas to form 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride. The method has the characteristics of cheap and readily available raw materials, high yield, mild reaction conditions and the like, and has a large-scale preparation value. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104086545-A |
| priorityDate | 2011-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.