http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102491862-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caacf483b6be9ae2d2677103a70559db |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C37-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C39-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-353 |
| filingDate | 2011-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_567f82e8729d50b0b8588d5983559373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1be927b7392295d4b6e5d64622166040 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c35947e6c9a1ffadf6d1982c45de590 |
| publicationDate | 2014-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102491862-B |
| titleOfInvention | Method for preparing biaryl compound in pure water |
| abstract | The invention discloses a method for preparing a biaryl compound in a pure water solution, which belongs to the technical field catalytic chemistry. The method is a method for preparing a biaryl compound by undergoing a Suzuki cross-coupling reaction on an aryl halide and aryl boronic acid. The method comprises the following steps of: adding an aryl halide, arylboronic acid, an alkali, a catalyst and a methoxy end-capped and polyethylene glycol-modified imidazole salt in the molar ratio of 0.5:0.75:1.0:(0.0025-0.005):0.01-0.02 into 1 mL of water; reacting at the temperature of 100 DEG C for 5-480 minutes; after reacting, adding 15mL of saturated saline solution for undergoing a quenching reaction; extracting a reaction product from a reaction mixture with 15 mL of acetic ether for three times; combining organic phases; concentrating a filtrate; and separating with column chromatography to obtain an analytically pure biaryl compound. The method has the characteristics that: the reaction is undergone in pure water serving as an environmentally-friendly solvent without adding any organic solvent; the problem of difficulty in reacting a water-soluble substrate in a pure water system is solved; and inert gas protection is not required in a reaction process, operation is easy, and industrial production is easy. |
| priorityDate | 2011-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.