http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102488657-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65682d3e437c225d79b93953b4b26392 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 |
| filingDate | 2011-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7e3787d1518a9d4773bc32e99c0e98f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_644002a1de1fd4baa903f1b7b98f1af6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eefd6859d1c450c471036c20b2bb6047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53c837f3ac019d1b7f47553e760ce951 |
| publicationDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102488657-B |
| titleOfInvention | Fullerenol solid lipid nano-particles, preparation method thereof, and application thereof |
| abstract | The invention belongs to the field of radiation protection, and specifically relates to nucleus-targeting fullerenol solid lipid nano-particles with a radiation protection function. The fullerenol solid lipid nano-particles comprises: stearic acid, cholesterol, lecithin, corn oil, Tween-80, fullerenol powder, and diethylstilbestrol. According to the invention, stearic acid, cholesterol, lecithin, corn oil, fullerenol powder, and diethylstilbestrol are sufficiently dissolved in ethanol; the mixture is well mixed; ethanol is removed by rotary evaporation; the mixture is slowly dropped into an aqueous solution of Tween-80 with a same temperature; when dropping is finished, the mixture is stirred and well mixed, such that C60(OH)24-SLN-E primary emulsion is obtained; the C60(OH)24-SLN-E primary emulsion is subject to high-pressure homogenizing, and is cooled, such that a required product is obtained. The fullerenol solid lipid nano-particles provided by the invention can penetrate various biological barriers and nuclear membranes, and carry fullerenol into nuclei with high efficiency. Therefore, free radicals in the nuclei can be removed, such that the radiation protection function can be realized. |
| priorityDate | 2011-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.