| abstract |
Provided are diphenylsulfide derivatives which have excellent S1P3 antagonistic activity and are useful as medicines. Intensive research has been conducted to prepare compounds with S1P3 antagonistic activity. As a result of intensive studies, it has been found that diphenyl sulfide derivatives represented by the general formula (1) have excellent S1P3 antagonistic activity. In the general formula (1), R 1 is a hydrogen atom, etc.; R 2 is an optionally substituted alkyl group with 1-6 carbon atoms, etc.; X is a methylene group that may be substituted by one or two fluorine atoms, etc.; Y is a hydrogen atom or the like; and Z is a halogen atom. [Formula 1] |