http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102470155-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L1-30 |
| filingDate | 2009-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102470155-B |
| titleOfInvention | Method for producing novel gynostemma pentaphyllum extracts having increased amounts of damulin A and damulin B and pharmaceutical composition for treating metabolic diseases using the same |
| abstract | The present invention relates to a use of an AMP-activated protein kinase (AMPK) activator for relieving and treating metabolic diseases wherein AMPK is an energy sensor and key enzyme for regulating lipid and glucose metabolism in a living body. When AMPK is activated, synthesis of lipid and cholesterol is inhibited; body fat is decreased; lowering of blood glucose is facilitated; and obesity, diabetes, and hyperlipidemia are relieved. In the present invention, novel compounds Damulin A (2alph,3belta,12belta-trihydroxydammar-20(2)-E,24-diene-3-O-[belta-D-glucopyranosyl-(1)-belta-D-glucopyranoside]) and Damulin B (2alpha,3belta,12belta-trihydroxydammara-20,24-diene-3-O-[belta-D-glucopyranosyl-(1)-belta-D-glucopyranoside]) are used as the AMPK activator for the active ingredients for relieving and treating metabolic diseases including obesity, diabetes, and hyperlipidemia. In addition, the present invention provides a method for increasing the amount of Damulin A or Damulin B which is the valid indicator for AMPK activation by treating Gynostemma pentaphyllum extracts at high temperature and high pressure. Therefore, the present invention also provides a use of novel Gynostemma pentaphyllum extracts with remarkably increased capacity of activating AMPK for relieving or treating metabolic diseases such as obesity, diabetes, and hyperlipidemia. |
| priorityDate | 2009-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 203.