http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102464594-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_500def13140adc2c5ff96ea7ee683045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 |
| filingDate | 2010-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af7be24613850a5cf7f058000cb6b0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c3128456164f1d5a187a2d3b9b60416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa58dd817f592dcd87f4927705480b4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28aff665704d6f617a65d822281d49dd |
| publicationDate | 2012-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102464594-A |
| titleOfInvention | The preparation method of the intermediate compound of pregabalin |
| abstract | The invention discloses a preparation method of an intermediate compound II of pregabalin, which comprises the following steps: (1) subjecting compound VI and XCH 2 COOR 2 to SN 2 substitution reaction to obtain compound I; (2) combining Wittig-Hornor reaction of compound I obtained in step (1) with isobutyraldehyde; wherein, R 1 is a C 1 -C 6 alkoxy group or a C 6 -C 10 aryl group, X is a halogen, and R 2 is a C 1 -C 6 alkyl group. The present invention also relates to a preparation method for intermediate compound V of pregabalin, which comprises the following steps: in a solvent, under the action of catalyst [Rh((Sc, Rp)-Duanpos)(COD)] BF 4 , Compound IV and hydrogen can be subjected to asymmetric hydrogenation reaction; wherein, M is H, C 1 -C 6 alkyl or t-BuNH 3 + . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105348126-A |
| priorityDate | 2010-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.