| abstract |
The present invention relates to compounds of formula I: The present invention provides compounds that inhibit, modulate and/or modulate PI3K and/or mTOR and are useful in the treatment of hyperproliferative diseases such as cancer in mammals. The present invention also provides methods for preparing the compounds, methods for using such compounds in mammals, especially humans, for the treatment of hyperproliferative diseases, and pharmaceutical compositions comprising such compounds. For example, cancers in which activity of PI3K-alpha, mTOR, or both contribute to the pathology and/or symptomology of the disease include breast cancer, mantle cell lymphoma, renal cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, NPM/ ALK-transformed anaplastic large cell lymphoma, diffuse large B-cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervical cancer, non-small cell lung cancer, small cell lung cancer, adenocarcinoma, colon cancer, rectal cancer Carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, pancreatic cancer, prostate cancer, thyroid cancer, anaplastic large cell lymphoma, hemangioma, glioblastoma, or head and neck cancer. |