| abstract |
The present invention provides a compound of formula (1) or its salt or tautomer, wherein X 1 is N or N + (O − ); X 2 is N or CH; Q is C 1-3 alkylene; R 1 selected from hydrogen, C 1-4 hydrocarbyl and hydroxy-C 2-4 hydrocarbyl; R 2 , R 3 and R 4 are the same or different and are each selected from hydrogen, fluorine, chlorine and methyl; Ar 1 is an optionally substituted mono Ring 5 or 6-membered aryl or heteroaryl ring or naphthyl ring containing 0, 1 or 2 ring heteroatoms selected from O, N and S, and Ar 2 is containing 1, 2 or 3 ring heteroatoms selected from Optionally substituted monocyclic 5 or 6-membered heteroaryl rings of O, N and S ring heteroatoms. Compounds of formula (1) are p70S6 kinase inhibitors and are useful in the treatment of proliferative diseases. |