| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e092ba7c0b4f2beba27b6420c0bd2ce |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate |
2010-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cb677f25b93c74be8a2b45bebde7afc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abdb54c692ecda4b6f44a7d871965f92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a2ad1c710699ab315954f756a818e2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a18eceb760073ba679684115d2c085e |
| publicationDate |
2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-102458398-B |
| titleOfInvention |
Pyrrolidine-substituted flavones as radiosensitizers in cancer therapy |
| abstract |
The present invention relates to a combination for the treatment of cancer, wherein the combination exhibits a synergistic effect. The combination comprises radiation and at least one cyclin-dependent kinase (CDK) inhibitor selected from a compound of formula I or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to a method of treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of the combination. The present invention also relates to the use of a CDK inhibitor selected from the compounds of chemical formula I as a radiosensitizer, the CDK inhibitor greatly improves the curative effect of radiotherapy for cancer, especially head and neck cancer. |
| priorityDate |
2009-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |