http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102453701-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01d74e1f4b646c6f83d40ae812413f8f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-15 |
| filingDate | 2010-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0f463cd36c91c243b77efd86a2fea07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_875e558c2bc0f6052441707a5e9734f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61e09f291cd027bda383cc2860ebb98c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d129ca0356e0f4abe4cae9e94949a5b0 |
| publicationDate | 2014-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102453701-B |
| titleOfInvention | Gene modified CDR3 delta transplanted gamma delta T lymphocyte and its antitumor purpose |
| abstract | The invention relates to a Gene modified CDR3 delta transplanted gamma delta T lymphocyte and its antitumor purpose. Retrovirus particles of a gamma delta TCR delta 2 chain and a gamma delta TCR delta 9 chain which contains an OT 3 sequence (FPSHTFHSTVVHT) are respectively packaged, the retrovirus particles are used for infecting normal human PBMC stimulated by an anti-CD3 antibody, the cell membrane surface expresses TCR gamma delta, the gene modified CDR3 delta transplanted gamma 9 delta 2T lymphocyte can be obtained, experiment proves that the cells possess cytotoxic effect on a plurality of tumor cells. The gene modified CDR3 delta transplanted gamma delta T lymphocyte and its antitumor purpose provide a novel method and a strategy for adoptive immunotherapy of the tumor. |
| priorityDate | 2010-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.