http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102453066-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6faf3905d59a3e8ee02915bea0f377f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f90c1df3857ee72900e0015c75caecd9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2010-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cec68a741e61953c63985c242d8d214 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_707fd44797aa577f394a0e5c53c73469 |
| publicationDate | 2012-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102453066-A |
| titleOfInvention | A kind of compound molecule and its preparation method and pharmaceutical composition |
| abstract | Provided are a complex molecule with good stability and long blood retention time, its preparation method and application. The composite molecule contains two at least 80% complementary nucleic acid strands X 1 and X 2 , the 5' end of X 1 is connected to the 3' end of X 2 through a linking group L 1 and/or the 5' end of X 2 is connected to The 3' end of X1 is linked by linking group L2 . The 5' end and/or 3' end of the two nucleic acid chains X1 and X2 of the composite molecule provided by the invention are connected by a linking group as shown in formula 1, so the nucleic acid chains are not easy to unwind and degrade, thereby greatly Improved nucleic acid stability and blood retention time. After the complex molecule is administered, in the cell, the Dicer enzyme present in the cell is used to release the locked nucleic acid in the complex molecule, so that the released double-stranded nucleic acid exerts its function, for example, siRNA inhibits the expression of the target gene. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662222-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662222-B |
| priorityDate | 2010-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.