abstract |
The present invention relates to therapeutic methods for preventing or treating cachexia, fever, weakness and/or fatigue in a patient in need thereof using antibodies and fragments thereof having binding specificity for IL-6. In preferred embodiments, the anti-IL-6 antibody is humanized and/or aglycosylated. Moreover, in preferred embodiments, these patients include those patients who exhibit (or are at risk of developing) elevated serum C-reactive protein levels. In another preferred embodiment, the patient's vitality or quality of life is preferably increased. |