http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102432466-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6dab0b3344ab01e596a21deac1ce195 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 |
| filingDate | 2011-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b76661d82b726d8f03b2735bef9f7f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6637803ae353fba3513266583e331883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1063729a5c89848cffec56e76ff56e9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f044e7168165c4777bf40ca5dd23f7e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39cabd84def317636993ed51cc314535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8d9760bf69e1f60871b13a7f83ca95d |
| publicationDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102432466-B |
| titleOfInvention | Preparation method of aliskiren intermediate |
| abstract | The invention relates to a preparation method of a compound, more specifically to a preparation method of an important intermediate (S)-2-isopropyl-4-oxobutyric acid methyl ester for synthesis of aliskiren. The preparation method provided by the invention comprises the following steps of: using isobutyraldehyde and nitromethane as raw materials, performing a Henry reaction and an elimination reaction to obtain corresponding conjugated nitroolefin, performing a Michael addition reaction between conjugated nitroolefin and acetaldehyde in the presence of a chiral catalyst to obtain (S)-4-methyl-3-(nitro methyl)pentanal, oxidizing the intermediate to obtain (S)-2-isopropyl-4-oxobutanoic acid, followed by methyl esterification to obtain (S)-2-isopropyl-4-oxobutyric acid methyl ester. The preparation method provided by the invention requires no low temperature, metal organic reagents or chiral separation, has advantages of easily obtained and low-priced raw materials and reagents, few synthesis steps, mild reaction condition and high yield, and is more suitable for industrial production. |
| priorityDate | 2011-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.