| abstract |
There is a need for a polymer conjugate of a physiologically active substance that can release a drug independently of an enzyme in the body and is expected to have a high therapeutic effect. The present invention provides a polymer conjugate of a physiologically active substance, wherein at least one of the side chain carboxyl groups of a block copolymer of a polyethylene glycol moiety and a polymer having two or more carboxyl groups is bonded with an amide bond With general formula (I) or general formula (II) In the formula, R 8 and R 9 independently represent a hydrogen atom or a (C1-C6) alkyl group that may have a substituent, and R 10 represents a hydrogen atom or a (C1-C40) alkyl group that may have a substituent group, (C1~C40) aralkyl groups that may have substituents, aryl groups that may have substituents, carboxy protected amino acid residues or sugar residues that may have substituents, CX-CY represents CH-CH or C =C (double bond), and A represents a residue obtained by removing any one of the one or more hydroxyl groups from a physiologically active substance having one or more hydroxyl groups. |