http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102417917-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49790ed5b8ddc5fa27a1d47732c612df |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06 |
| filingDate | 2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d7d7c97f7253aa7a6399207c0f44612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe9893e4b346752d64c41a255d2a236b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d08a9dcffabb832ef634e804cca5634d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a119ca469ae31c849a4ac03146d1f8b3 |
| publicationDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102417917-B |
| titleOfInvention | Method for enzymatically synthesizing chiral acetic cyanhydrin ester by directly using cyanogen salt as cyanogens source |
| abstract | The invention discloses a method for enzymatically synthesizing chiral acetic cyanhydrin ester by directly using cyanogen salt as a cyanogens source. The method includes the following steps: enzyme, the cyanogen salt, water, organic solvent and acetic acid are sequentially added into a reaction vessel and uniformly mixed, aldehyde compound is dripped, reaction takes place under the condition of room temperature, and the reaction time is 6 to 100 hours; after the reaction is finished, separated organic phase is dipped into mixture containing acetic anhydride and pyridine to react under the room temperature for 3 to 24 hours; and after saturated sodium bicarbonate and water washing, drying, concentration and column chromatography purification, the corresponding target compound is obtained. The method directly uses the cyanogen salt as the cyanogens source and the cheap, easy-to-obtain acetic acid as a proton donor, and effectively inhibits the spontaneous chemical addition reaction of HCN and aldehyde ketone by controlling the proportion between the water and the organic phase, so that enzymatic reaction under hydroxynitrile lyase can be efficiently carried out. The method is simple and safe, can obtain high yield of high-optical purity chiral acetic cyanhydrin ester, and has high industrial application value. |
| priorityDate | 2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.