http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102408363-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e1c1696d12fb09adbae21a4fea1b6fb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-28 |
| filingDate | 2011-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22799c55ce2c4521fad7565cd8302ee0 |
| publicationDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102408363-B |
| titleOfInvention | Method for synthesizing busulfan |
| abstract | The invention discloses a method for synthesizing busulfan, which is characterized in that: 1,4-butanediol and methanesulfonic anhydride is taken as main materials; at least one of triethylamine, pyridine, diethylisopropyl amine or sodium bicarbonate is taken as alkali; acetone, tetrahydrofuran, acetonitrile or diethyl ether is taken as solvent; and the whole reaction process is carried out under the protection of nitrogen gas. The invention also further discloses a method for re-crystallizing busulfan. The methanesulfonic anhydride is used to replace methanesulfonyl chloride so that chlorine-containing product is avoided being produced in the synthesis technology; excessive methanesulfonic anhydride can be reacted with the alkali to form salt, and the salt can be ensured to be all removed after being repeatedly washed by large amounts of water, so that types and content of impurities in the busulfan can be effectively controlled. The method disclosed by the invention is simple, reasonable and easy to operate. The busulfan prepared by re-crystallization can be directly used for preparing injection. |
| priorityDate | 2011-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.